Limestone calcined clay cement (LC3) systems are considered one of the most promising options for lowering costs and environmental impact of concrete in the decades to come. Consequently, research and development worldwide aims at identifying and characterizing suitable mineral resources and deposits for fabricating LC3 cement, as well as developing concrete mix design guidelines and establishing the mechanical and durability performance of LC3 concrete. Concrete with three different clinker levels and four different clays from South Africa and Tanzania were produced and compared with two reference mixes. The first part of this publication concerned mechanical properties of LC3 concrete made with various African raw materials. This paper concerns durability properties obtained on the various mix compositions.